Information and products associated with novel coronavirus research
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??Overview
- Background to coronaviruses
- Recent research into novel coronavirus
- Products to support coronavirus research
- Antibodies and proteins specific for human coronaviruses
- ACE2 receptor antibodies and ELISA kits
- ACE2 related targets
- Digital spatial profiling of proteins in COVID-19 tissue samples
- Rapid SARS-CoV-2 lateral flow assays
??Coronaviruses, named after their crown-like shape, were first identified in the 1960s and are associated with a range of respiratory symptoms. Cases such as Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV) can cause aggravated symptoms in humans and can lead to pneumonia, severe acute respiratory syndrome, and death1,2?. SARS-CoV-2 (previously known as 2019-nCoV), which causes the COVID-19 disease, is the latest coronavirus strain to be identified. ?
Coronavirus research
Chinese scientists identified the novel coronavirus as a group 2B CoV, distinct from the SARS-CoV3,4,5. Genome sequencing demonstrated that SARS-CoV-2 (2019-nCoV) shares a 79.5% sequence identity with SARS-CoV and 96% of identity with a bat coronavirus6.
To access host cells, coronaviruses attach to specific host cellular receptors via the spike protein7. Thus, SARS-CoV utilizes angiotensin converting enzyme II (ACE-2) host cell receptor, whereas MERS-CoV uses CD26 (DPP4)8. The results of several recent studies suggest that SARS-CoV-2 can use the same cell entry receptor, ACE-2, as SARS-CoV6,9,10.
At the time of publishing this page, no vaccine or specific antiviral treatment exists for SARS-CoV-2. Scientists are searching for potential vaccines and therapeutic agents targeting SARS-CoV-2 or host cell components (eg host cell receptors) necessary for viral replication.
Products to support coronavirus research
Abcam offers a variety of tools used to help understand and accelerate infectious disease research, including SARS-CoV-2, the coronavirus that causes COVID-19. To help researchers navigate quickly to relevant products, listed below are antibodies and proteins specific for the detection and analysis of human coronaviruses.
Our product range for cytokine detection and research of SARS-CoV-2 can be found here.
If there is a product you need for COVID-19-related research that is not listed here, please contact us and we may be able to help.
?Antibodies and proteins specific for human coronaviruses
| Name | abID | Application |
| Anti-SARS-CoV-2 Spike Glycoprotein S1 antibody [CR3022] | ab273073 | Neutralizing, ELISA |
| Recombinant Anti-SARS-CoV-2 Spike Glycoprotein S1 antibody [CR3022] - Chimeric | ab273074 | Neutralizing, ELISA |
| Recombinant Human coronavirus SARS-CoV-2 nucleocapsid protein (His tag) | ab273530 | ELISA, WB |
| Anti-SARS E antibody | ab22055 | WB |
| Anti-SARS spike glycoprotein antibody [3A2] - Coronavirus | ab272420 | WB, ICC/IF, Flow Cyt |
| Recombinant SARS nucleocapsid protein (Coronavirus) | ab49042 | ELISA, WB |
| Anti-SARS-CoV-2 envelope protein antibody - Coronavirus | ab272503 | ELISA |
| Anti-SARS-CoV-2 spike glycoprotein antibody - Coronavirus | ab272504 | ELISA |
| Anti-SARS spike glycoprotein antibody [1A9] | ab273433 | ELISA, WB, ICC/IF, Flow Cyt, IP |
| Anti-SARS nucleocapsid protein antibody [6H3] | ab273434 | ELISA, WB, ICC/IF, Flow Cyt, IP |
See a complete list of coronavirus-specific products.
SARS-CoV-2 ELISA kits
Sandwich-based ELISAs for the quantitative measurement of COVID-19 antigens in serum samples.
ACE2 antibodies and ELISA kits
| Name | abID | Application | Species |
| Human ACE2 ELISA Kit | ab235649 | ELISA | Human |
| Human ACE2 Antibody Pair - BSA and Azide free | ab244135 | ELISA | Human |
| Recombinant Anti-ACE2 antibody [EPR4435(2)] | ab108252 | IHC-P, IP, WB | Mouse, Rat, Human |
| Recombinant Anti-ACE2 antibody [EPR4435(2)] - BSA and Azide free | ab239924 | IHC-P, IP, WB | Mouse, Rat, Human |
| Anti-ACE2 antibody | ab15348 | IHC-Fr, WB, IHC-P | Cat, Human, Ferret, Macaque monkey, Bat |
| Recombinant Human ACE2 protein | ab151852? | SDS-PAGE, HPLC | Human |
| Recombinant Human ACE2 protein (Fc Chimera) | ab273687 | SDS-PAGE, HPLC, ELISA | Human |
| Recombinant Human ACE2 (mutated H374 N + H378 N) protein (Fc Chimera) | ab273885 | SDS-PAGE, HPLC, ELISA | Human |
Anti-ACE2 antibody [EPR4436] ?Anti-ACE2 antibody [EPR4436] | ab108209 | WB, IP, IHC-P | Human |
| DX600 ACE2 inhibitor | ab273525 |
See a complete list of products targeting ACE2 receptors.
ACE2 related targets
??Please find below a list of targets that may help to accelerate your research on ACE-2 receptors.
| Name | AbID | Application | Species |
| Recombinant human TMPRSS2 protein | ab112364 | SDS-PAGE | Human |
| Anti-TMPRSS2 antibody [EPR3862] | ab109131 | ICC/IF, WB, IHC-P | Mouse, Rat, Human |
| Recombinant anti-TMPRSS2 antibody [EPR3861] | ab92323 | WB, IHC-P | Mouse, Rat, Human, Cynomolgus monkey, Rhesus monkey, Common marmoset |
| Recombinant anti-DPP4 antibody [EPR20819] | ab215711 | WB, IHC-P | Human |
| Recombinant anti-DPP4 antibody [EPR18215] | ab187048 | WB, IHC-P, IHC-Fr | Mouse, Rat |
| Human DPP4 ELISA kit | ab252365 | ELISA | Human |
| Recombinant anti-MCP1 antibody [EPR21025] | ab214819 | WB, ICC/IF, Flow Cyt, IP (unsuitable for IHC-P) | Human |
| Human MCP-1 ELISA kit | ab179886 | ELISA | Human |
| Recombinant anti-CD13 antibody [EPR4058] | ab108310 | WB, IHC-P, ICC/IF (Unsuitable for Flow Cyt, IP) | Mouse, Rat, Human |
| Human CD13 ELISA kit | ab239427 | ELISA | Human |
Digital spatial profiling of proteins in COVID-19 tissue samples
In the study of SARS-CoV-2 and COVID-19, rapid and reproducible spatial analysis of clinically relevant tissue samples is challenging due to the fixation processes required to prevent disease transmission.
Developed in partnership with NanoString, the COVID-19 GeoMx-formatted Antibody Panel provides a custom panel which will be run with the GeoMx Immune Profiling Core to enable spatial analysis of 96 proteins involved in the immune response to SARS-CoV-2 infection.
This new panel further expands the protein content available on the GeoMx? Digital Spatial Profiler to enable high-plex analysis of key biological pathways mapped to specific regions within infected tissues. The data generated demonstrates the application of this new tool in SARS-CoV-2 formalin-fixed paraffin-embedded (FFPE) tissue samples and how it can be used to better understand the processes underlying infection, pathogenesis and therapeutic response.
This is another solution to support the study of the immune response in COVID-19 disease research.
| Product | abID |
| COVID-19 GeoMx-formatted Antibody Panel |
?Rapid SARS-CoV-2 lateral flow assays
See below our rapid coronavirus lateral flow assays that enable the detection of novel coronavirus IgG or IgM antibodies in 8-10 minutes.?
| Name | abID | Sample type | Detects | Time to results |
Novel Coronavirus IgG Antibody Detection Kit | ab272243 | Human serum, plasma, whole blood | Coronavirus N-Protein IgG antibodies | 8-10 min |
Novel Coronavirus IgM Antibody Detection Kit | ab272244 | Human serum, plasma, whole blood | Coronavirus N-protein IgM antibodies | 8-10 min |
Abcam’s products are intended for research use only, not for use in diagnostic, therapeutic or any other purposes. If you are interested in the commercial use of our products, please connect with us at partnerships@abcam.com.
For the latest information on the outbreak, please visit the World Health Organization (WHO) website.
References
1. https://www.who.int/ith/diseases/sars/en/
2. https://www.who.int/emergencies/mers-cov/en/
3.Virological.org. Novel 2019 Coronavirus Genome. Available online: http://virological.org/t/novel-2019-coronavirus-genome/319 (accessed on 28 January 2020).
4. GSAID Database. 2020 Coronavirus. Available online: https://www.gisaid.org/CoV2020/ (accessed on 28 January 2020).
5. https://www.ncbi.nlm.nih.gov/nuccore/MN908947
7. Lim, Y.X., Ng, Y.L., Tam, J.P., Liu, D.X. Human Coronaviruses: A Review of Virus-Host Interactions. Diseases. 4:26 (2016).
8. Lu, G., et al. Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature. 500, 227-231 (2013).
?10. Letko, M.C., Munster, V. Functional assessment of cell entry and receptor usage for lineage B β-coronaviruses, including 2019-nCoV. bioRxiv 2020.
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